6-Phosphogluconic acid

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6-Phosphogluconic acid is a potent and competitive inhibitor of phosphoglucose isomerase (PGI).

6-Phosphogluconic acid is a potent and competitive inhibitor of phosphoglucose isomerase (PGI).The activity of phosphoglucose isomerase was inhibited intensely and competitively by 6-Phosphogluconic acid, with an apparent Ki of 0.048 mM for glucose 6-phosphate and 0.042 mM for fructose 6-phosphate as the substrate.(In Vitro):With glucose 6-phosphate as the substrate, at concentrations from 0.05 to 0.5 mM, the activity of the enzyme was inhibited completely in the presence of 0.5-2.0 mM 6-Phosphogluconic acid. With 0.05-0.2 mM fructose 6-phosphate as the substrate, it was inhibited greater than or equal to 85% at the same concentrations of the inhibitor. No significant changes were observed in the values of Km, Vmax, and Ki for phosphoglucose isomerase in the brain of 6-aminonicotinamide-treated rats.

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Others

Other Targets

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921-62-0

276.1

C6H13O10P

>98% (HPLC)

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O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years